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Physiology Core

Overview of Services

We are focused on assessing physiological and metabolic phenotypes for novel mouse models of human disease which have been developed by our Center and Institute investigators. Such analyses provides insight into “on target” and “off target” tissue phenotypes, and will add substantial value towards understanding the physiological implications of changes in regulators of stem and progenitor cell formation. To complement assays for biochemical markers of skeletal and soft tissue metabolism, Promethion metabolic cages provide 87 distinct readings per second on mouse activity, oxygen consumption, CO2 production, food intake, weight and water consumption. This output is coupled with dual energy X-ray absorptiometry/NMR analysis that measures in vivo body composition cross-sectionally or longitudinally.


A Seahorse XF96 analyzer that measures oxygen consumption rate (OCR) and extracellular acidification rate (ECAR) of live cells in a multi-well plate, interrogating key cellular functions such as mitochondrial respiration and glycolysis is also available. The XF96 provides bioenergetic data utilizing three agents in a mitochondrial or glycolytic rate test paradigm. In addition a comprehensive metabolic report is provided by the Core director to the investigator that emphasizes the metabolic phenotype of the animal, alternative experiments or biomarkers to be considered, and suggestions for further studies.


Core Director
Clifford Rosen


Core Manager
Victoria DeMambro


Research Associate
Phuong Le


Research Associate
Jennifer Daruszka

Location and hours of operation

  Hours             Location

  Staffed Hours:  Monday - Friday, 9:00am -6:00pm 
  Open Facility Hours:  24/7  

            81 Research Drive
            Scarborough, ME,   04074

Links and Resources

  1. Maine Medical Center Research Institute


Name Role Phone Email Location
Victoria DeMambro, MS
Core Manager
Room 1617